ABSTRACT
Background and Objective: Despite of the COVID-19 pathogenesis and severity of the infection still completely unclear, but the human's genetic variation in gene participate in SARS-COV2 infectivity, inflammation and immunity response might have a great association with severity of clinical out-comes of nCoV-2019 disease. This study evaluates the impact of CD14-159 and IL4 genotypes on the severity of SARS-COV2 infection. Materials and method: This research have been done with one hundred individuals from Al-Qadisiyah governorate in Iraq, whom infected with SARA-COV2. The patients have been divided into three subgroups according to severity of clinical symptoms;mild, moderate and severe groups. RFLP-PCR technique has been worked out to specify genes polymorphisms.